BASI BIOLOGICHE DEL COMPORTAMENTO
MODULO II
NEUROENDOCRINOLOGIA DEL COMPORTAMENTO (2010-2011)


Prof. GianCarlo Panzica

Aggiornamento: 19/1/2012

ATTENZIONE!! ARTICOLI DA COMMENTARE PER L'ESAME: QUI

Lezioni in formato PDF e articoli di approfondimento


SITI DA VISITARE:
- Society for Behavioral Neuroendocrinology
- International Neuroendocrine Federation
- Gruppo Italiano per le Scienze Neuroendocrine

- Congresso Steroids and Nervous System (Torino, 19-23 Febbraio 2011)


0 - INTRODUZIONE AL CORSO -
(pdf)
- Brain facts - breve corso in Inglese sull'organizzazione del SNC (pdf file)
- Brain Briefings - Una pagina web a cura della Society for Neuroscience che riporta brevi articoli su vari aspetti delle Neuroscienze (qui)
- Neuroendocrinology Briefings - Una pagina web a cura della Società Inglese di Neuroendocrinologia che riporta brevi articoli (qui)
1- Sistema endocrino - Ipotalamo - (pdf)
Letture consigliate:
- Raisman (1997) - The Discovery of the Neural Control of the Pituitary Gland.   (pdf)
- Guillemin (2005) - Hypothalamic hormones a.k.a. hypothalamic releasing factors (pdf)
- Charlton (2008) Hypothalamic Control of Anterior Pituitary Function: A History (pdf)

2 - Neurotrasmettitori, neuropeptidi, ormoni (pdf
Letture consigliate:
- Kladieva (1996) -Storia dei neuropeptidi  (file 1, 2, 3, 4)
- Stone (1998) - Receptors: structure and function (pdf file 150 K)
- Kuiper (1998) The Estrogen Receptor b Subtype: A Novel Mediator of Estrogen Action in Neuroendocrine Systems (pdf file 5.5 Mb)
- Gobinet (2002) Molecular action of androgens (pdf file 1.5 Mb)
- McPhaul (2002) Androgen receptor mutations and androgen insensitivity (pdf file 200 kb)
- Tetel (2009) Modulation of steroid action in the central and peripheral nervous systems by nuclear receptor coactivators (pdf file 450 Kb)


MODULO NEUROANATOMIA



15 - Differenze sessuali: fenotipo e comportamento (pdf)


        Letture consigliate
        - McEwen (1999) - Permanence of brain sex differences and structural plasticity of the adult brain (pdf file circa 48 K)

16 - Steroidi sessuali e sistema nervoso (pdf)
Letture consigliate
- Toran-Allerand (1999) - Novel mechanisms of estrogen action in the brain (pdf file circa 400 K)
- Rissman (1999) Sex with knockout models: behavioral studies of estrogen receptor alpha (pdf)
- Pettersson (2001) Role of estrogen receptor beta in estrogen action (pdf file circa 300 Kb)
- Wang (2001) Morphological abnormalities in the brains of estrgen receptor beta knockout mice (pdf)
- Melcangi (2006) Neuroactive steroids: old players in a new game (pdf file circa 1.2 Mb)
- Panzica (2008) The endocrine nervous system: Source and target for neuroactive steroids (pdf file 150 Kb)

  17 - Controllo del differenziamento sessuale cerebrale (pdf 1, pdf 2)

Letture consigliate:
- Panzica (1995) - Structural sex differences in the brain (pdf file circa 500 K)
- Panzica (1996) - The sexually dimorphic medial preoptic nucleus of quail. (pdf file circa 1,3 MB)
- Cooke (1998) - Sexual differentiation of the vertebrate brain (pdf file circa 200 K)
- Swaab (2001) - Structural and functional sex differences in the human hypothalamus (pdf file circa 70 K)
- Arnold (2003) Two perspectives on the origins of sex differences in the brain (pdf file 150 Kb)
- The sexual brain: Special Issue Nature 2004 (pdf file 4.2 Mb)
- McCarthy (2005) When a sex difference is not a sex difference? (pdf file 800 Kb)
- Bakker (2008) Role for estradiol in female-typical brain and behavioral sexual differentiation (pdf file circa 700 K)
- Iiijima (2001) Sex Differences in Children’s Free Drawings: A Study on Girls with Congenital Adrenal ... (pdf file 300 Kb)
- Panzica (1998) - Organizational effects of estrogens on Brain vasotocin ........ (pdf)
- Panzica (2001) - Steroid-induced plasticity in the sexually dimorphic vasotocinergic innervation .......  (pdf file circa 2,3 MB)
- Han (2003)  - Organizational Effects of Testosterone, Estradiol, and Dihydrotestosterone on Vasopressin .....(pdf file circa 200 K)
- Plumari (2002) - Changes in the Arginine-Vasopressin Immunoreactive Systems in Male Mice Lacking .... (pdf file circa 450 K)
- De Vries (2006) - Sexual differentiation of central vasopressin and vasotocin systems in vertebrates (pdf)

Rassegna bibliografica in Italiano: Dimorfismi cerebrali nell'uomo (pdf)


18 - Aromatasi e attivazione del comportamento sessuale (pdf 1pdf 2, pdf 3, pdf 4)

Letture consigliate
- Roselli (1998) - Sexual differentiation of aromatase activity in the rat brain (pdf file 700Kb)
- Absil (2001) - The control of preoptic aromatase ............ (pdf file circa 11 Mb)
- Balthazart (2003) Multiple mechanisms control brain aromatase activity (pdf file 600Kb)
- Balthazart (2006) - Is brain estrogen a hormone or a neurotransmitter? (pdf file circa 1.7 Mb)
- Garcia-Segura (2008) Aromatase in the Brain: Not Just for Reproduction Anymore (pdf file 200 Kb)


19
- Neurosteroidi (pdf 1, pdf 2, pdf 3)

Letture consigliate
- Mensah (1996) - Localization of 17beta hydrosteroid deidrogenase ............ (pdf file circa 450 K)
- Compagnone (2000) - Neurosteroids: Biosynthesis and functions ......... (pdf file circa 900 K)
- Mellon (2001) - Biosynthesis and action of neurosteroids (pdf file circa 600 K)
- Lambert (2001)- Modulation of native and recombinant GABA(A) receptor ........  (pdf file circa 500 K)
- Stocco (2001) StAR protein and the regulation of steroid hormone biosynthesis (pdf file circa 2.6 Mb)
- Stoeffels (2003) Neurosteroids in the human brain (pdf file 1.5 Mb)
- Lavaque (2006) Steroidogenic acute regulatory protein in the brain (pdf file 150Kb)
- Frye (2009) Neurosteroids’ effects and mechanisms for social, cognitive, emotional, and physical functions (pdf file)


  20- Distruttori Endocrini (pdf)

Letture consigliate
- Patisaul (2005) Phytoestrogen action in the adult and developing brain (pdf file circa 200 Kb)
- Panzica (2007) Effects of xenoestrogens on the differentiation of behaviorally-relevant neural circuits (pdf file circa 1.3 Mb)
- Gore (2008) Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems (pdf file)
- Gore (2009) Environmental Endocrine Disruption of Brain and Behavior (pdf file)
- Panzica (2009) Effects of Xenoestrogens on the Differentiation of Behaviorally Relevant Neural Circuits in Higher Vertebrates (pdf file)



21 - Il sistema a GnRH (pdf)

Letture consigliate
- Dubois (2002) Evolutionary development of three  gonadotropin-releasing hormone (GnRH) (pdf file 100 Kb)
- Legan (2003) Estrogen receptor alpha and beta immunoreactivity in GnRH neurons (pdf file 150 Kb)
- Kauffman (2004) Emerging functions of GnRH in mammalian physiology and behaviour (pdf file 350 Kb)
- Millar (2005) GnRHs and GnRH receptors (pdf file 1 Mb)
- Clarkson (2006) Postnatal development of Kisspeptin neurons ........ (pdf file 600 Kb)
- Tsutsui (2007) The general and comparative biology of GnIH (pdf file 1.5 Mb)
- Herbison (2008) Estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons in the rodent (pdf file 900 Kb)
- Smith (2008) Kisspeptin signalling in the brain (pdf file 400 Kb)

22 - Pubertà (pdf)

Letture consigliate
- Rogol (2002) Androgens and puberty (pdf file 150 Kb)
- Sisk (2003) Puberty: a finishing school for male social behavior (pdf file 250 Kb)
- Parent (2003) The timing of normal puberty ........ (pdf file 650 Kb)
- Romeo (2003) Puberty: a period of both organizational and activational ................ (pdf file 120 Kb)
- Ojeda (2006) The neuroendocrine regulation of puberty (pdf file 500 Kb)
- Navarro (2007) Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin (pdf file 300 Kb)


23 - Feromoni e risposte neuroendocrine (pdf)

Letture consigliate

- Segovia (1996) Searching for Sex Differences in the Vomeronasal Pathway (pdf file 136 Kb)
- Zufall (2001) From odor and pheromone transduction to the organization of the sense of smell (pdf file 80 Kb)
- Halem (2001) Sex Difference and Steroid Modulation of Pheromone-Induced Immediate ........... (pdf file 900 Kb)
- Halpern (2003) Structure and function of the vomeronasal system: an update ...................... (pdf file 1.5 Mb)
- Segovia (2006) Sexual dimorphism in the vomeronasal system of the rabbit ..........................(pdf 1.2 Mb)
- Cutler (1998) Pheromonal influences on sociosexual behavior in men (pdf file 160 Kb)
- McCoy (2002) Pheromonal influences on sociosexual behavior in young women (pdf file 80 Kb)

 
24a -
Ormone tiroideo (pdf)
Letture consigliate
- Wu (2000) - Gene regulation by thyroid hormone (pdf file circa 250 K)
- Chan (2000) - Thyroid hormone and central nervous system development (pdf file circa 150 K)
- Thomson (2000) Thyroid hormone action in neural development (pdf)
- Koibuchi (2000) - Thyroid Hormone Action and Brain Development (pdf file circa 500 K)
- Zhang (2000) - The mechanism of action of thyroid hormones (pdf file circa 200 K)
- Howdeshell (2002) A model of the development of the brain as a construct of the thyroid system (pdf file 200Kb)
- Viguirie (2003) Effect of thyroid hormone on gene expression (pdf file 150 Kb)

24b - Ormone tiroideo e comportamento (pdf), modelli sperimentali e fotoperiodismo (pdf)
 Letture consigliate
- Anderson (2001) - Thyroid Hormones and the Brain (pdf file circa 100 K)
- Smith (2002) - Thyroid hormones, brain function and cognition (pdf file 250 K)
- Yoshimura (2003) Light-induced hormone conversion of T4 to T3 regulates .........(pdf file 300Kb)
- Watanabe (2004) Photoperiodic regulation of type 2 deiodinase gene ........ (pdf file 200Kb)
- Morgan (2008) Photoperiodic Signalling Through the Melatonin Receptor Turns Full Circle (pdf file)

25a - Sistema a vasopressina/vasotocina e ossitocina (pdf)
Letture consigliate
- De Vries & Panzica (2006) Sexual differentiation of central vasopressin and
vasotocin systems in vertebrates: different mechanisms, similar endpoints. (pdf file)

25b - Ormoni neuroipofisari e comportamento di coppia (pdf)

Letture consigliate
- Insel (2000) Neuropeptides and the evolution of social behavior (pdf)
- Pitkow (2001) Facilitation of affiliation and pair-bond formation by vasopressin receptor (pdf)
- Ferguson (2002) The neuroendocrine basis of social recognition (pdf)
- Young (2004) The neurobiology of pair bonding (pdf file 1.2 Mb)
- Bielsky (2004) Oxytocin, vasopressin, and social recognition in mammals (pdf file 500 Kb)

26 - Comportamento parentale (pdf)

Letture consigliate
- Lonstein (2000) Sex differences in the parental behavior of rodents (pdf file 60 Kb)


27 - Asse Ipotalamo-Ipofisi-Surrene (pdf1, pdf2)

Letture consigliate
- Glucocorticoid receptor beta (1999) (pdf file 1 and 2  250 Kb each)
- Reul (2000) The brain mineralcorticoid receptor:............ (pdf file 2Mb)
- Nichols (2001) Do glucocorticoids contribute to brain aging? (pdf file 1 Mb)
- McEwen (2002) Effects of adverse experiences for brain structure and function (pdf file 350 Kb)
- Karakalis (1997) CRH and the immune system (pdf file 650 Kb)
- Herman (1997) Neurocircuitry of stress:........... (pdf file 1 Mb)
- Fujioka (1999) The effects of prenatal stress on the development of hypothalamic paraventricular neurons (pdf file 800 Kb)
- Walker (2001) Increased co-localization of CRF and AVP in lactating rats ...... (pdf file 1Mb)
- Viau (2001) Androgens alter CRF and AVP mRNA within forebrain sites ...... (pdf file 300 Kb)
- Smagin (2001) The role of CRH in behavioral responses to stress (pdf file 400 Kb)


28 - Comportamento ed Epigenetica (pdf)

Letture consigliate
- Francis (2002) - Naturally Occurring Differences in Maternal Care are Associated with the Expression of Oxytocin ..(pdf file circa 150 K)
- Weaver (2004) Epigenetic programming by maternal behavior (pdf file 700 Kb)
- Weaver (2004) Early environmental regulation of hippocampal glucocrticoid ......... (pdf file 11.6 Mb)
- Meaney (2005) Maternal care as a model for experience-dependent chromatin plasticity? (pdf file 200Kb)
- Stolzenberg (2011) Epigenetic methodologies for behavioral scientists (pdf file 800Kb)


 
29- Controllo assunzione del cibo - Leptina (pdf), NPY - MSH - Orexina - GHrelina (pdf)

Letture consigliate

- Baskin (1999) - Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake .... (pdf file 210 K)
- Casaneuva (1999) - Neuroendocrine Regulation and Actions of Leptin (pdf file 450 K)
- Ahima (2000) - Leptin (pdf file 150 K)
- Elmqist (2001) - Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin (pdf file 80 K)
- Samson (2000) - The Hypocretin/Orexin Story (pdf file 270 K)
- Morton (2001) - The NPY/AgRP neuron and energy homeostasis (pdf file 210 K)
- Cowley (2003) The Distribution and Mechanism of Action of Ghrelin ........... (pdf file 700 K)
- Winne (2005) Appetite control (pdf file 500 Kb)
- Oberto (2003) - Evidence of altered NPY content and NPY Y1 receptor gene expression ... (pdf file 400K)
- Zammaretti (2007) Sex dependent regulation of hypothalamic NPY-Y1 receptor gene expression ... (pdf file 600 Kb)

30 - Comportamento aggressivo: basi neuroendocrine ed anatomiche (pdf, pdf)

Letture consigliate
- Everts (1997) Differential lateral septal vasopressin in wild-type rats (pdf 500 Kb)
- Ferris (1997) Vasopressin/Serotonin interactions .......... (pdf 1.1 Mb)
- Goodson (1999) Effect of intraseptal vasotocin .............. (pdf 400 Kb)
- Bester (2001) Vasopressin and aggression ......................(pdf 400 Kb)
- Nelson (1997) Effects of Nitric Oxide on Neuroendocrine Function and Behavior (pdf 400 Kb)
- Gammie (2000) Maternal and mating-induced aggression............. (pdf 400 Kb)
- Nelson (2001) Molecular basis of aggession (pdf 100 Kb)
- Chiavegatto (2003) Interaction of nitric oxide and serotonin in aggressive behavior (pdf 200 Kb)
- Popova (2006) From genes to aggressive behavior: the role of serotoninergic system (pdf 200 Kb)


  31- Riassunto dei principali circuiti studiati (pdf)