Nome
del laboratorio:
Laboratorio di Neuroscienze dello Sviluppo. Facoltà Medicina e
Chirurgia.
Università Campus Bio-Medico di Roma
Responsabile:
Flavio Keller,
f.keller@unicampus.it
Componenti:
Filippo Biamonte, f.biamonte@unicampus.it
Ramona Marino, r.marino@unicampus.it
Flavia Salvadori (amministrativa),
f.salvadori@unicampus.it
Linee di Ricerca:
- Reelin e neurosviluppo.
Modelli sperimentali utilizzati:
- Reeler mouse, L7 GFP/reeler.
Metodologie utilizzate:
- Stereologia, IHC, IF, WB, PCR,
Fenomica: analisi UVs, Tissue culture
Pubblicazioni (2004-2008):
- Persico AM, D’Agruma L, Zelante L, Militerni L, Bravaccio
C,
Schneider C, Melmed C, Trillo S, Montecchi F, Elia M,
Palermo M, Rabinowitz D, Pascucci T, Puglisi_Allegra S,
Reichelt L, Muscarella L, Guarnieri V, Melgari JM , Conciatori M and
Keller F (2004) Enhanced APOE2 transmission rates in families with
autistic probands. Psych Genet. 14, 73_82.
- Laviola G, Adriani W, Gaudino C, Marino R, Keller F (2006)
Paradoxical
effects of prenatal acetylcholinesterase blockade on neuro_behavioral
development and drug_induced stereotypies in reeler mutant mice.
Psychopharmacology 187, 331_44.
- Marrone MC, Marinelli S, Biamonte F, Keller F, Sgobio C,
Amassari-Teule
M, Bernardi G, Mercuri NB (2006) Altered cortico-striatal plasticity
and related behavioural parameters in reeler mice. European Journal of
Neuroscience 24, 2061-2070.
- Panteri R, Mey J, Zhelyaznik N, D'Altocolle A, Del Fa A,
Gangitano C,
Marino R, Lorenzetto E, Buffelli M, Keller F (2006) Reelin is
transiently expressed in the peripheral nerve during early development
and is upregulated following nerve crush. Mol. Cell. Neuroscience
32,133_42.
- Panteri R, Paiardini A, Keller F (2006) A 3D_model of
Reelin subrepeat
regions predicts Reelin binding to carbohydrates. Brain Research 1116,
222_30.
- Lorenzetto E, Panteri R, Marimo R, Keller F, Buffelli M
(2008) Impaired
nerve regeneration in reeler mice after peripheral nerve injury. Eur J
Neurosci 27(1):12-9.
- Luccarini Ilaria, Ballerini Clara, Biagioli Tiziana,
Biamonte Filippo,
Bellucci Arianna, Casamenti Fiorella. Atorvastatin and
minocycline, effective combination in experimental autoimmune
encephalomylities (2008) Experimental Neurology. Doi:10.1016
- Biamonte F, Assenza G, Panteri R, Marino R, Caruso D,
Scurati S,
Garcìa Yague J, Garcìa-Segura LM, Cesa R, Strata P,
Melcangi RC, Keller F. Effects of neuroactive steroids and Reelin
gene dosage on Purkinje cell survival during development. Submitted The
Journal of Neuroscience 28-01-2008
Book chapters:
Keller F, Panteri R, Biamonte F. Interaction between Genetic
Vulnerability and Neurosteroids in Purkinje cells as a Possible
Neurobiological Mechanism in Autism Spectrum Disorders: A.P. Zimmerman
(Ed.) Autism: Current Theories and Evidence. Humana Press. (2008) In
press
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